To take longer to fall into strap -sleeping may be an early sign
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To take longer to fall into strap -sleeping may be an early sign

The National Institute of Neurological Disorders and Stroke says “Alzheimer’s disease and Alzheimer’s disease -related dementia (AD/ADRD) refer to the most common forms of dementia.” Dementia does not have a cure, but research on potential risk factors and early detection remains ongoing.

The authors of the current study wanted to understand more about the timing of REM sleep and its relationship with Alzheimer’s disease and Alzheimer’s disease and related dementia. is a stage of the sleep cycle when lively dreaming occurs. REM sleep helps with information processing and consolidation.

REM LATENCY (Reml) is the time it takes for someone to reach strap for the first time after falling asleep.

For this study, researchers examined REM sleep, and several biomarkers that researchers noted were associated with Alzheimer’s disease and Alzheimer’s disease and related dementia.

This research included 128 participants. Sixty four of the participants had Alzheimer’s disease, forty had mild cognitive impairment, and the rest had normal cognition. All participants were at least fifty years old. Apart from Alzheimer’s disease, researchers excluded participants who had other neurodegenerative disorders such as Parkinson’s disease. They also had several other exclusion criteria, such as sleep -related movement disorders or the use of antipsychotic drugs.

Researchers collected data about the participants’ medical history, and all participants underwent skull MRI, blood work and a number of cognitive tests before the start of the study.

Participants did a sleep study overnight PolysomnographyWhich can examine brain waves and other physical functions such as eye movement and breathing during sleep. Researchers could identify when the participants’ REM sleep occurred.

Participants underwent pet searches to look at Amyloid beta levels, which may indicate Alzheimer’s disease. Researchers also examined the levels of three plasma bio markers. Increase In plasma, phosphorylated Tau at Treonin 181 (P-Tau 181) may indicate Alzheimer’s disease, and increases in neurofilament lights (NFL) may indicate neurode generation. Decreased In plasma, brain derivative neurotrophic factor (BDNF) may also indicate Alzheimer’s disease.

Researchers also conducted statistical analyzes and adjusted for factors such as body mass index, gender and diabetes mellitus. They also adjusted for Apoe ε4 Status, which is a gene that can increase someone’s risk to Alzheimer’s disease.

How delayed strap -sleep affects the brain

The study’s results revealed that participants with the longest Reml had higher levels of P-TAU181 and amyloid beta and lower levels of plasma brain-derived neurotrophic factor compared to participants with the shortest REML. These results were independent of the participants’ cognitive status or APOE ε4 status.

Even after adjusting for the possibility of false positive results, the link between amyloid beta and plasma-bravely neurotrophic factor remained in a protein involved in brain cell growth meaning. This suggests a meaningful link between these two factors that may be important for understanding Alzheimer’s disease.

In addition, it was linked to higher levels of P-TAU181, a protein associated with certain neurological conditions such as Alzheimer’s to have less REM sleep and deep sleep (also known as slow wave sleep). Slow wave sleep is the sleep stage when people experience the deepest rest. However, this association did not remain significantly after considering the possibility of false results.

Study author Yue LengPhD, associate professor at the Department of Psychiatry and Behavioral Sciences, Bakar Computational Health Sciences Institute (BCHSI), University of California, San Francisco, noted the following to Medical news today:

“REM sleep, especially the time it takes to get into REM sleep, is potentially important for Alzheimer’s disease. The importance of this sleep measurement has largely been ignored earlier. We do not know if the correlation is causal, but REM sleeping can potentially serve as a marker and help with early detection of AD (Alzheimer’s disease). More research is needed to understand the biological basis for REM -SAVENNEN and its consequences for AD (if the relationship is causal). “

This research has some restrictions. First, it cannot determine that delayed REM sleep is a cause of Alzheimer’s disease. Since it was cross -section, it cannot also note the direction for the associations it identified.

It also included a fairly small number of participants, all he -Chinese and at least fifty or older. The number of participants in each diagnosis group was also small, and this could have limited the actual statistical power needed to compare “associations with cognitive diagnoses.”

While researchers found that participants with mild cognitive deterioration or Alzheimer’s disease took longer to get to REM sleep than the participants without cognitive reduction, these results did not reach a statistically significant level.

Future research could benefit from studies with larger sample sizes and greater diversity, as well as from including younger participants.

Researchers also chose to focus on Plasma P-Tau 181 instead of P-TAU217. They note that P-TAU217 is more sensitive to predicting Alzheimer’s disease progression.

The attitude for the sleep study could have led to environmental interruptions, which could have affected sleep measurement accuracy. Also, since the sleep study was only one night, it may not completely reflect what the participants’ sleep patterns usually look like. Researchers also note that many participants did not have a percentage of sleep time that was slow wave sleep, and this can affect the ability to generalize the results.

One of the study authors explained conflicts of interest, and the study received financing support from two grants.

Giulio TaglialtelaPHD, Deputy Chairman of Brain Health, Head of Moody Brain Health Institute, research professor and Lawrence J. Del Papa Distinguished Chair in Neurodegenerative Disease Research Professor with UTMB Department of Neurology, which was not involved in the study, notified the study, noted on the study, noted if study, noted if study, noted on study, noted on study, noted on study, noted on study, noted on study, noted on study, noted on study, noted on study, noted.

“(It is) a well-executed pilot clinical study that suggests that the delay in the first REM section is associated with increased biomarkers for Alzheimer’s disease. While the observation is interesting and deserves further development, the current study is a limited number of patients, which jeopardize their full statistical power. “

This study highlights how REM sleep is probably also important when it comes to dementia research and not just slow wave sleep.

Alex Dimitriu, MDDouble Board Certified in Psychiatry and Sleep Medicine and founder of Menlo Park Psychiatry & Sleep Medicine, which was also not involved in the study, noted:

“The results in this document change the focus from slow wave sleep to REM sleep as another research area in Alzheimer’s disease. More generally, these findings add the importance of all stages in our sleep cycle, including REM sleep. “

All in all, more research is required to understand the complete clinical consequences of data. However, it is possible that the addressing of prolonged reml can potentially modify the risk of Alzheimer’s disease and Alzheimer’s disease and related dementia. Identifying long -term reml can also help with some dementia detection early.

“Relationships between sleep patterns and the risk of developing dementia have been noted earlier. This study points to a specific disorder (delayed first REM section) and casts some light on the specificity of sleep/dementia connection. Surveillance delayed first REM sections may represent a marker to predict later development of dementia. But many more studies are needed to get this observation to clinical relevance. “
– giulio taglialtela, phd